| Document ID (ISN) | 43742 |
| CIS number |
85-738 |
| ISSN - Serial title |
0105-1873 - Contact Dermatitis |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Andersen K.E., Hamann K. |
| Title |
How sensitizing is chlorocresol? Allergy tests in guinea pigs versus the clinical experience |
| Bibliographic information |
July 1984, Vol.11, No.1, p.11-20. 29 ref. |
| Abstract |
The sensitising potential of the biocide chlorocresol, used widely in pharmaceutical products, was judged strong using the guinea pig maximisation test (GPMT) and doubtful in the less sensitive open epicutaneous test. An optimal sensitising concentration above which no further increase in the sensitisation rate occurred was found. Rechallenge after 2 weeks showed a marked decrease in sensitivity. Consecutive human patch tests with 2% chlorocresol showed 11 reactions among 1,462 patients tested, but none were explainable and reproducible during re-tests and provocative tests indicating that the GPMT overestimated the sensitisation potential. |
| Descriptors (primary) |
sensitization dermatitis; allergy tests; biocides; chlorocresol |
| Descriptors (secondary) |
eczema; pharmaceutical industry; human experiments; animal experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Skin diseases
Phenols and phenolic compounds
|
