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Document ID (ISN)43077
CIS number 84-1997
ISSN - Serial title 0018-8247 - Higiena i zdraveopazvane
Year 1983
Convention or series no.
Author(s) Mirkova E., Antov G.
Title Experimental evaluation of the risk of prenatal pathology due to warfarin, a coumarin rodenticide
Original title Eksperimentalna ocenka na riska ot prenatalna patologija pri văzdejstvie na kumarinovija rodenticid varfarin [in Bulgarian]
Bibliographic information Mar. 1983, Vol.26, No.6, p.476-482. Illus. 33 ref.
Abstract The embryotoxic and teratogenic effect of the coumarin preparation warfarin, the active ingredient of the Bulgarian rodenticide formulation Raton, was studied in rats. The prenatal toxicity of the preparation (peroral administration) was determined at doses of 8-0,04mg/kg (LD50 oral for rats, 16mg/kg). Warfarin, at all levels studied, was embryotoxic and teratogenic. It increased the level of embryonal lethality, provoked a characteristic haemorrhagic syndrome in the foetus, induced structural malformations of the hind limbs, internal hydrocephalus and haemorrhages in the brain tissue and abdominal cavity. Measures are proposed for the protection of women working in the production of coumarin rodenticides.
Descriptors (primary) embryotoxic effects; coumarin; teratogenic effects; rodenticides; warfarin
Descriptors (secondary) ingestion; biochemical tests; animal experiments; metabolic disturbances
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Heterocyclic compounds