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Document ID (ISN)42963
CIS number 84-1973
ISSN - Serial title 0355-9831 - Työterveyslaitoksen tutkimuksia
Year 1983
Convention or series no.
Author(s) Sorsa M., Donner M., Falck K., Heinonen T., Hemminki K., Husgafvel-Pursiainen K., Lindbohm M.L., Mäki-Paakkanen J., Norppa H., Vainio H.
Title Genotoxic effects of occupational chemical exposure
Original title Työperäisen kemiallisen altistumisen genotoksiset vaikutukset [in Finnish]
Bibliographic information 1983, No.3, p.170-191. Illus. 102 ref.
Abstract A study of groups of workers in the reinforced plastics, rotogravure printing and rubber industries. The reactivity, metabolism and mutagenicity of some potential problem chemicals were studied in the laboratory. Worker exposure to genotoxic agents was then assessed by determining the mutagenicity of urine samples, with bacteria as the indicator organisms. Examination of lymphocytes from the workers showed a marked elevation in chromosomal aberrations in reinforced plastics workers, who are exposed to styrene; rubber workers, who are exposed to several agents, showed frequencies of chromosomal aberration only slightly higher than control values, and printing industry workers, exposed to toluene, showed no increase at all. Smoking was associated with chromosome defects. There was no elevated frequency of spontaneous abortion among women in the rubber industry as a whole, and no teratogenic effect was observed. A subset of the women in the rubber industry was at risk of spontaneous abortion, but no cause was identified.
Descriptors (primary) mutagens; rubber industry; plastics converting industry; teratogens; genetic effects; printing industry
Descriptors (secondary) smoking; abortion; exposure tests; chromosome changes; teratogenic effects; epidemiologic study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Printing, photography and photocopying industry
Rubber industry
Genetic factors in reaction to exposures