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Document ID (ISN)42495
CIS number 84-1394
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 1983
Convention or series no.
Author(s) Rycroft R.J.C.
Title Allergic contact dermatitis from a novel diamino intermediate, 5-((2-aminoethyl)thiomethyl)-N,N-dimethyl-2-furanmethanamine, in laboratory synthesis
Bibliographic information Nov. 1983, Vol.9, No.6, p.456-458. Illus.
Abstract Half of the 12 chemists working on the development of a new pharmaceutical product developed rashes as a result of exposure to the title compound. The case of one of these workers is described in detail. Patch testing showed that the final product was not allergenic. The unsubstituted amino group of the 2-aminoethyl moiety is apparently essential for the title compound's activity as a hapten. Although the chemists working with the compound wore rubber gloves, the occurrence of new cases of dermatitis was halted only by transfer of the synthesis to a pilot plant with a completely closed system.
Descriptors (primary) furan derivatives; allergens; pharmaceutical industry; skin allergies; eczema; amines
Descriptors (secondary) case study; 5-((2-aminoethyl)thiomethyl)-N,N-dimethyl-2-furanm
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Pharmaceutical industry
Skin diseases
Heterocyclic compounds