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Document ID (ISN)42325
CIS number 84-1369
Year 1983
Convention or series no. Arbete och hälsa 1983:33
Author(s) Holmberg B., Kronevi T., Ackevi S., Ekner A.
Title Carcinogenicity testing of p-phenylenediamine by intraperitoneal injection in newborn mice (neonatal study)
Original title Prövning av carcinogen aktivitet hos p-fenylendiamin med intraperitoneal injektion på nyfödda möss (neonatalförsök) [in Swedish]
Bibliographic information Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1983. 35p. Illus. 5 ref.
Abstract Daily doses of 30mg p-phenylenediamine (PPD) per kg body weight were administered for 5 days to 51 male and 55 female neonates, which were sacrificed after 26 and 52 weeks. PPD did not affect body weight or survival. Tumours (lymphomas, alveolar adenomas) occurred in 30.1% compared with 18.2% in a control group given the vehicle (oil) alone, and 82.1% in controls receiving urethane. Compared with the vehicle group, PPD slightly increased the overall tumour rate.
Descriptors (primary) carcinogenicity tests; phenylenediamine
Descriptors (secondary) animal experiments; p-phenylenediamine
Document type E - Books, reports, proceedings
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Aromatic amines