Document ID (ISN) | 42325 |
CIS number |
84-1369 |
Year |
1983 |
Convention or series no. |
Arbete och hälsa 1983:33
|
Author(s) |
Holmberg B., Kronevi T., Ackevi S., Ekner A. |
Title |
Carcinogenicity testing of p-phenylenediamine by intraperitoneal injection in newborn mice (neonatal study) |
Original title |
Prövning av carcinogen aktivitet hos p-fenylendiamin med intraperitoneal injektion på nyfödda möss (neonatalförsök) [in Swedish] |
Bibliographic information |
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1983. 35p. Illus. 5 ref. |
Abstract |
Daily doses of 30mg p-phenylenediamine (PPD) per kg body weight were administered for 5 days to 51 male and 55 female neonates, which were sacrificed after 26 and 52 weeks. PPD did not affect body weight or survival. Tumours (lymphomas, alveolar adenomas) occurred in 30.1% compared with 18.2% in a control group given the vehicle (oil) alone, and 82.1% in controls receiving urethane. Compared with the vehicle group, PPD slightly increased the overall tumour rate. |
Descriptors (primary) |
carcinogenicity tests; phenylenediamine |
Descriptors (secondary) |
animal experiments; p-phenylenediamine |
Document type |
E - Books, reports, proceedings |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
|
Browse category(ies) |
Aromatic amines
|