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Document ID (ISN)41894
CIS number 84-834
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1983
Convention or series no.
Author(s) Franchini I., Cavatorta A., Falzoi M., Lucertini S., Mutti A.
Title Early indicators of renal damage in workers exposed to organic solvents
Bibliographic information 1983, Vol.52, No.1, p.1-9. Illus. 33 ref.
Abstract 438 workers from 11 factories and 29 dry-cleaning shops were studied: 57 exposed to perchloroethylene; 118 painters exposed to benzene homologues at 5 metalworking factories; 51 exposed to styrene vapours in glass-fibre-reinforced plastics boat and silo manufacture; and 212 workers exposed to C5-C7 alkanes; also 2 control groups (80 and 81 workers). Renal function was investigated by determination of total proteinuria, albuminuria and urinary muramidase and β-glucuronidase. There was little evidence of renal damage due to solvent exposure. Total proteinuria was significantly increased in workers exposed to alkanes and to styrene, but this finding did not correspond to other changes. Any renal damage appeared to be mild and tubular rather than glomerular. The methods are intended as screening procedures and not as a substitute for clinical diagnosis of renal diseases.
Descriptors (primary) early diagnosis; renal damage; exposure tests; organic solvents; dry cleaning
Descriptors (secondary) tetrachloroethylene; toluene; styrene; proteinuria; xylene; comparative study; plastics converting industry; alicyclic hydrocarbons; aliphatic hydrocarbons; determination in urine; metalworking industry
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the kidney and the urinary system
Laundries and dry cleaning
Biological monitoring