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Document ID (ISN)41808
CIS number 84-717
ISSN - Serial title 0140-6736 - Lancet
Year 1984
Convention or series no.
Author(s) Hirst M., Tse S., Mills D.G., Levin L., White D.F.
Title Occupational exposure to cyclophosphamide
Bibliographic information 28 Jan. 1984, No.8370., p.186-188. 10 ref.
Abstract Cyclophosphamide (CP) is a widely used anticancer drug that is rapidly metabolised to a number of mutagenic products. Urine samples from 2 nurses were analysed for CP by gas chromatography after they had prepared CP for patients. CP appeared in several urine samples, in amounts not related to the amounts of drug handled. To find out if CP might also be absorbed through the skin, urine samples from 5 volunteers were analysed after CP was applied to their skin. Variable quantities of CP were identified, but in most cases after a longer waiting period that in the case of the nurses.
Descriptors (primary) mutagens; hospitals; cyclophosphamide; antineoplastic drugs
Descriptors (secondary) determination in urine; skin absorption
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Heterocyclic compounds
Health care services