| Document ID (ISN) | 41469 |
| CIS number |
84-488 |
| ISSN - Serial title |
0098-4108 - Journal of Toxicology and Environmental Health |
| Year |
1982 |
| Convention or series no. |
|
| Author(s) |
Kluwe W.M., Haseman J.K., Douglas J.F., Huff J.E. |
| Title |
The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice |
| Bibliographic information |
Oct.-Nov. 1982, Vol.10, Nos.4-5, p.797-815. Illus. 43 ref. |
| Abstract |
Groups of 50 male and female rats and male and female mice were fed diets containing 6000 or 12000 (rats) or 3000 or 6000 (mice) mg di(2-ethylhexyl) phthalate (DEHP)/kg for 103 consecutive weeks. Treatment with DEHP did not affect survival rates for rats or mice, compared with controls, nor did it alter the amount of food consumed. Mean body weight gains of the treated animals were less than those of controls. Treatment with DEHP caused liver tumours in both sexes of mice and rats. The combined incidence of animals with hepatocellular carcinomas or neoplastic nodules was significantly greater than that in controls for male rats ingesting 12000mg/kg and female rats ingesting 6000mg/kg. The combined incidence of animals with hepatocellular carcinomas or adenomas was significantly greater than that in controls for male mice ingesting 3000mg/kg. 20 of the 57 hepatocellular carcinomas diagnosed in DEHP-treated mice had metastasised to the lung. |
| Descriptors (primary) |
carcinogens; plasticizers; toxicology; bis(ethylhexyl) phthalate |
| Descriptors (secondary) |
animal experiments; plastics industry; carcinogenic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Phthalates
Esters and salts
|
