| Document ID (ISN) | 41390 |
| CIS number |
84-470 |
| ISSN - Serial title |
0047-1879 - Japanese Journal of Industrial Health - Sangyō-Igaku |
| Year |
1983 |
| Convention or series no. |
|
| Author(s) |
Misumi J., Koyama W., Miura H. |
| Title |
Two cases of "green-tobacco sickness" in tobacco harvesters and absorption of nicotine through the skin in the rat |
| Bibliographic information |
1983, Vol.25, No.1, p.3-9. Illus. 11 ref. |
| Abstract |
These are the first cases reported in Japan, occurring in both non-smokers and non-drinkers. Symptoms are dizziness, nausea and generalised weakness, and develop after exposure to wet raw tobacco leaves, probably as a result of absorption of nicotine through the skin. Studies in rats showed the minimum toxic dose of nicotine through the skin to be 21mg/kg body weight. The toxic dose in humans might be <1.96mg/kg body weight. |
| Descriptors (primary) |
nicotine; tobacco farming; green-tobacco sickness |
| Descriptors (secondary) |
Japan; animal experiments; skin absorption; case study |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Heterocyclic compounds
Agriculture
|
