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Document ID (ISN)41390
CIS number 84-470
ISSN - Serial title 0047-1879 - Japanese Journal of Industrial Health - Sangyō-Igaku
Year 1983
Convention or series no.
Author(s) Misumi J., Koyama W., Miura H.
Title Two cases of "green-tobacco sickness" in tobacco harvesters and absorption of nicotine through the skin in the rat
Bibliographic information 1983, Vol.25, No.1, p.3-9. Illus. 11 ref.
Abstract These are the first cases reported in Japan, occurring in both non-smokers and non-drinkers. Symptoms are dizziness, nausea and generalised weakness, and develop after exposure to wet raw tobacco leaves, probably as a result of absorption of nicotine through the skin. Studies in rats showed the minimum toxic dose of nicotine through the skin to be 21mg/kg body weight. The toxic dose in humans might be <1.96mg/kg body weight.
Descriptors (primary) nicotine; tobacco farming; green-tobacco sickness
Descriptors (secondary) Japan; animal experiments; skin absorption; case study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Heterocyclic compounds