| Document ID (ISN) | 40716 |
| CIS number |
83-1958 |
| ISSN - Serial title |
0047-1879 - Japanese Journal of Industrial Health - Sangyō-Igaku |
| Year |
1982 |
| Convention or series no. |
|
| Author(s) |
Misumi J., Nagano M., Nomura S. |
| Title |
An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane |
| Bibliographic information |
1982, Vol.24, No.5, p.475-484. Illus. 46 ref. |
| Abstract |
The compounds 2-octanone (2-O) and 2-hexanol (2-H) were administered daily as 400mg/kg doses to rats for 5 days per week for 21 weeks in order to determine the molecular structure associated with polyneuropathy. Treatment with 2-O resulted only in slight inhibition of weight gain and narcotic effects after injection. The same dose of 2-H resulted in hypersalivation, gait disturbances, crossing of hind limbs and a failure of normal growth. Retardation of the conduction velocity in the motor and sensory nerve fibres and the prolonged motor latencies of the tail nerves began to appear after week 14 when 9.6g total dose had been administered. The neurotoxic potency of 2-H appears to be greater than that of hexane but less than that of methyl butyl ketone, 2,5-hexanediol or 2,5-hexanedione. |
| Descriptors (primary) |
neurotoxic effects; toxicology; hexanols; ketones |
| Descriptors (secondary) |
2-octanone; animal experiments; 2-hexanol; hexane |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Diseases of the nervous system
Ketones
|
