| Document ID (ISN) | 40477 |
| CIS number |
83-1621 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Bonitenko Ju.Ju., Bočarov N.V., Lišenko V.V. |
| Title |
Effect of ethyl alcohol on some indices of ethylene chlorohydrin toxicity |
| Original title |
Vlijanie ėtilogo spirta na nekotorye pokazateli toksičnosti ėtilenhlorgidrina [in Russian] |
| Bibliographic information |
Sep. 1981, No.9, p.44-45. 9 ref. |
| Abstract |
Simultaneous administration of ethyl alcohol increased the LD50 of ethylene chlorohydrin (β-chloroethanol, a solvent for cellulose derivatives used in the paper and pharmaceutical industries) regardless of the route of administration (peroral or percutaneous). The necrotic lesions produced in the liver and kidney by ethylene chlorohydrin were also reduced in number and extent by ethanol. Blood concentrations of the chlorohydrin were raised by ethanol administration, which suggests that the protective effect is due to competitive inhibition of chlorohydrin metabolism to chloroacetaldehyde. |
| Descriptors (primary) |
ethanol; toxicology; antidote treatment; 2-chloroethanol; inhibition of metabolism |
| Descriptors (secondary) |
metabolic detoxication; hepatotoxic effects; pharmaceutical industry; nephrotoxic effects; paper and paper products industry; animal experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
|
