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CISDOC database

Document ID (ISN)40427
CIS number 83-1654
ISSN - Serial title 0140-6736 - Lancet
Year 1982
Convention or series no.
Author(s) Cartwright R.A., Rogers H.J., Barham-Hall D., Glashan R.W., Ahmad R.A., Higgins E., Kahn M.A.
Title Role of N-acetyltransferase phenotypes in bladder carcinogenesis: A pharmacogenetic epidemiological approach to bladder cancer
Bibliographic information 16 Oct. 1982, Vol.II, No.8303, p.842-846. 18 ref.
Abstract A large excess of patients with bladder cancer who have been exposed to N-substituted aryl compounds in production of dye intermediates have the slow phenotype of the enzyme N-acetyltransferase. Acetylator phenotyping in hospital patients with bladder cancer and controls is reported. Clerical workers and engineers using machine oils had slow-acetylator frequencies that were not significantly different from controls. All but 1 of 23 dye workers were slow acetylators. The results were highly significant. It is suggested that acetylator status could be used to identify susceptible individuals in potentially hazardous occupations.
Descriptors (primary) aromatic amines; enzyme activity; dyestuff industry; individual susceptibility; bladder tumour
Descriptors (secondary) carcinogens; comparative study; pre-employment medical examinations
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Aromatic amines
Chemical industry
Diseases of the kidney and the urinary system