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Document ID (ISN)40417
CIS number 83-1609
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1981
Convention or series no.
Author(s) Vasilenko N.M., Zvezdaj V.I.
Title Possibility of mathematical prediction of some criteria of toxicity of nitro and amino benzenoid compounds
Original title Vozmožnosti matematičesko prognozirovanija nekotoryh kriteriev toksičnosti nitro- i aminosoedinenij benzol'nogo rjada [in Russian]
Bibliographic information Aug. 1981, No.8, p.50-52.
Abstract Tabulation of the LD50 values of 22 aminobenzenoids and 21 nitrobenzenoids showed that their acute toxicities increase with increasing molecular weight; coefficients of linear regression equations expressing this relationship were calculated. Two-factor and multifactor correlation analysis also revealed correlations between LD50 and the levels of haemoglobin, oxyhaemoglobin, methaemoglobin and sulfhaemoglobin in the blood of experimental animals.
Descriptors (primary) aromatic amines; aromatic nitro compounds; prediction formulae; toxicology
Descriptors (secondary) haemoglobin; animal experiments; mathematical analysis; haematotoxic effects; lethal dose 50
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Aliphatic nitro compounds
Aromatic amines