| Document ID (ISN) | 40237 |
| CIS number |
83-1387 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Izrajlet L.I., Ustinenko A.N., Silkane V.S. |
| Title |
Toxicological characteristics of barbituric and thiobarbituric acids |
| Original title |
Toksikologičeskaja harakteristika barbiturovoj i tiobarbiturovoj kislot [in Russian] |
| Bibliographic information |
May 1981, No.5, p.50-51. 3 ref. |
| Abstract |
Animal experiments were undertaken to determine the toxicity, risk potential and tentative safe exposure level of barbituric and thiobarbituric acids, which are handled in the pharmaceutical industry. Barbituric acid did not affect the mucous membranes of the eye and showed no cumulative effect. Repeated administration of barbituric acid over a period of a month produced some morphological changes in the liver and kidney. Barbituric acid had a depilatory effect when rubbed into the skin. A tentative TLV of 5mg/m3 is proposed. The behaviour of thiobarbituric acid was very similar. It affected the spleen as well as the liver and kidney on repeated administration, and sensitised the skin to subsequent application. A tentative TLV of 2mg/m3 is proposed. The LD50 of both compounds was greater than 5000mg/kg for all animals tested. |
| Descriptors (primary) |
threshold limit values; USSR; pharmaceutical industry; thiobarbituric acid; toxicology; barbituric acid |
| Descriptors (secondary) |
allergens; hepatotoxic effects; nephrotoxic effects; animal experiments; barbiturates |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Pharmaceutical industry
Occupational exposure limits
Heterocyclic compounds
|
