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Document ID (ISN)39932
CIS number 83-1006
ISSN - Serial title 0047-1879 - Japanese Journal of Industrial Health - Sangyō-Igaku
Year 1982
Convention or series no.
Author(s) Katahira T., Teramoto K., Horiguchi S.
Title Experimental studies on the acute toxicity of tetrahydrofuran in animals
Bibliographic information 1982, Vol.24, No.4, p.373-378. Illus. 35 ref.
Abstract 20% tetrahydrofuran (THF) in various doses was given intraperitoneally and by inhalation to rats and mice. The intraperitoneal LD50 was 1,900-2,900mg/kg according to the solvent and animal used. LC50 was 21,000ppm when inhaled for 3h by rats. There were no significant effects of 100-200ppm THF for 3h in rats except for slight local irritant symptoms. Irritant and central nervous system symptoms occurred with inhalation of 5,000ppm THF.
Descriptors (primary) tetrahydrofuran; organic solvents; acute toxicity
Descriptors (secondary) animal experiments; lethal concentration 50; lethal dose 50
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Heterocyclic compounds