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CISDOC database
| Document ID (ISN) | 38845 |
| CIS number |
82-1993 |
| ISSN - Serial title |
0009-9309 - Clinical Toxicology |
| Year |
1981 |
| Convention or series no. |
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| Author(s) |
Frontali N., Amantini M.C., Spagnolo A., Guarcini A.M., Saltari M.C., Brugnone F., Perbellini L. |
| Title |
Experimental neurotoxicity and urinary metabolites of the C5-C7 aliphatic hydrocarbons used as glue solvents in shoe manufacture |
| Bibliographic information |
1981, Vol.18, No.12, p.1357-1367. 31 ref. |
| Abstract |
Rats were exposed to hexane, cyclohexane, pentane, heptane, and 2- and 3-methylpentane at 500-5,000ppm for 9-10h/day, 5-6 days/week for 7-30 weeks. None of the animals developed signs of neuropathy. Animals treated with hexane at 5,000ppm for 14 weeks or 2,500ppm for 30 weeks developed the typical giant axonal degeneration. No such alterations were found in rats subjected to the other solvents. Urinary metabolites of the various solvents were determined: 2-hexanol was the metabolite of hexane, while 2,5-hexanedione was present in smaller amounts. 2,5-hexanedione appears to reach an effective level at its site of action, during intermittent treatment with hexane, with difficulty; this explains the high concentrations necessary to cause polyneuropathy. |
| Descriptors (primary) |
neurotoxic effects; adhesives; aliphatic hydrocarbons; shoe industry; organic solvents |
| Descriptors (secondary) |
pentane; hexane; 2-methylpentane; heptane; cyclohexene; urinary metabolites; animal experiments; 3-methylpentane |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
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| Browse category(ies) |
Footwear, leather and fur industry
Diseases of the nervous system
Aliphatic and alicyclic hydrocarbons
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