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Document ID (ISN)38526
CIS number 82-1698
ISSN - Serial title 0019-8366 - Industrial Health
Year 1981
Convention or series no.
Author(s) Suzuki Y., Toda K., Koike S., Yoshikawa H.
Title Cadmium, copper and zinc in the urine of welders using cadmium-containing silver solder
Bibliographic information 1981, Vol.19, No.4, p.223-230. Illus. 17 ref.
Abstract Urine samples from 12 male welders aged 20 to 50 years who had been engaged in work with cadmium-containing silver solder for 3-23 years were analysed for cadmium (Cd), copper (Cu), and zinc (Zn) and compared with samples from 5 controls. Mean concentration values of Cd, Cu, and Zn for welders were 26, 2.4 and 2.6 times those of controls. A linear relation was found between urine concentrations of Cd, and both Cu and Zn. In chromatographic analyses of samples from 2 welders suspected of suffering from Cd-induced renal injury, the metallothionein fraction contained Cd and Cu but not Zn, and the Cu content of this fraction was much greater than the Cd content. The Cd and Cu in this fraction represented 6 and 10% of totals; the remaining Cd and Cu were recovered from high molecular weight protein and low molecular weight non-protein fractions. Urinary Zn was present in both of these fractions. Cd accumulation affects the excretion of Cu and Zn in urine, and urinary excretion of metallothionein containing Cd and Cu may be involved in Cd-induced renal injury.
Descriptors (primary) copper; zinc; cadmium; soldering and brazing; nephrotoxic effects; renal damage
Descriptors (secondary) renal function tests; determination in urine; urine monitoring
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Inorganic substances
Cadmium and compounds
Diseases of the kidney and the urinary system
Welding and cutting
Copper and compounds