| Document ID (ISN) | 38516 |
| CIS number |
82-1695 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Zober A., Schaller K.H., Gossler K., Krekeler H.J. |
| Title |
Pentachlorophenol and liver-function: A study on occupational exposed collectives |
| Original title |
Pentachlorophenol und Leberfunktion: Eine Untersuchung an beruflich belasteten Kollektiven [in German] |
| Bibliographic information |
1981, Vol.48, No.4, p.347-356. 12 ref. |
| Abstract |
Studies were carried out on 2 groups of workers exposed to pentachlorophenol (PCP) in the production and application of wood preserving products. The investigations involved measuring the external (in ambient air) and the internal (in urine and plasma) PCP concentrations as well as determining biochemical and immunological data for the evaluation of possible effects on the liver. The air concentrations of PCP were well below the MAK value of 500µg/m3. The plasma concentrations ranged from 0.02-2.4µg/ml; the renal excretion of PCP varied between 6 and 2.111µg/g creatinine. No correlation was found between the duration and degree of exposure to PCP and the PCP concentrations in the biological materials. In 6 persons the immunological investigations yielded remarkable findings. No dose-effect relation was proved for the rise in immunoglobulines, interpreted as the result of an increased mesenchymal activity. The biochemical investigations revealed elevated serum GLDH activities in both groups. |
| Descriptors (primary) |
wood preservatives; hepatic disorders; pentachlorophenol |
| Descriptors (secondary) |
exposure tests; hepatotoxic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Phenols and phenolic compounds
Alcohols
|
