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CISDOC database
Document ID (ISN) | 38454 |
CIS number |
82-1678 |
ISSN - Serial title |
0019-8366 - Industrial Health |
Year |
1982 |
Convention or series no. |
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Author(s) |
Nomiyama K., Nomiyama H., Yotoriyama M., Matsui K. |
Title |
Sodium dodecyl sulfate acrylamide gel electrophoretic studies on low-molecular-weight proteinuria, an early sign of cadmium health effects, in rabbits |
Bibliographic information |
1982, Vol.20, No.1, p.11-18. Illus. 13 ref. |
Abstract |
Rabbits received subcutaneous injections of 0.5mg cadmium (Cd)/kg for 42 weeks. The effects observed were: in the first week, a gradual increase in urine Cd; in the third week, slight low-molecular-weight (LMW) proteinuria, proteins of molecular weight (MW) 12,000 and 25,000; in the sixth week, slight proteinuria, proteins of MW 67,000; in the 11-13th weeks, aminoaciduria, glycosuria, proteinuria, and LMW proteinuria. Proteins of MW 12,000 and 25,000 increased in urine earlier than proteins of MW 67,000, and the presence of LMW proteins was an effective index for screening for early effects of Cd. Cd-treated rabbits had 60-80% of proteins of MW 67,000 in their urine and only 10% of LMW proteins, suggesting that Cd affects both tubules and glomerules. |
Descriptors (primary) |
early diagnosis; toxicology; cadmium; nephrotoxic effects; proteinuria |
Descriptors (secondary) |
renal dysfunction; electrophoresis; animal experiments |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
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Broad subject area(s) |
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Browse category(ies) |
Diseases of the kidney and the urinary system Cadmium and compounds Inorganic substances
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