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CISDOC database

Document ID (ISN)38453
CIS number 82-1677
ISSN - Serial title 0019-8366 - Industrial Health
Year 1982
Convention or series no.
Author(s) Nomiyama K., Nomiyama H., Yotoriyama M.
Title Low-molecular-weight proteins in urine from rabbits given nephrotoxic compounds
Bibliographic information 1982, Vol.20, No.1, p.1-10. Illus. 25 ref.
Abstract Rabbits were given 0.5mg cadmium (Cd)/kg by subcutaneous injection 6 times a week for 32 weeks. The main protein component in the urine of these animals had a molecular weight (MW) of ≥67,000 suggesting tubular and glomerular dysfunction. Low MW proteins were found, in addition, in the urine of animals given a single injection of uranium (U), chromium (Cr), or mercury (Hg). The MW distribution of proteins in the urine of these animals was very similar to that of Cd-treated rabbits. Low MW tubular reabsorption of phosphorus was >80%.
Descriptors (primary) mercury; uranium; toxicology; chromium; nephrotoxic effects; cadmium; proteinuria
Descriptors (secondary) animal experiments; renal dysfunction
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Inorganic substances
Diseases of the kidney and the urinary system
Mercury and compounds
Cadmium and compounds