| Document ID (ISN) | 36947 |
| CIS number |
82-200 |
| ISSN - Serial title |
0372-7726 - Yokohama Igaku (Yokohama Medical Journal) |
| Year |
1980 |
| Convention or series no. |
|
| Author(s) |
Ochiai S. |
| Title |
Hygienic studies on workers engaged in producing synthetic heatresisting enamel wire. Mixed toxicity of N-dimethylacetamide and N-methylpyrrolidone |
| Bibliographic information |
30 Oct. 1980, Vol.31, No.5, p.327-338. Illus. 20 ref. |
| Abstract |
The effects of exposure to mixed vapours of N-dimethylacetamide (DMA) and N-methyl-pyrrolidinone (MP) on workers producing heat-resistant enamel wire, were compared with the toxicological effects of the same substances on rats and mice. In workers, haemoglobin and leukocyte levels in peripheral blood increased with long-term exposure and relatively high values of glutamic-oxalacetic transaminase (GOT) and glutamic-pyruvic tansaminase (GPT) were observed from time to time during the 2-year study. In rats, exposure to vapour and intraperitoneal injection of DMA and MP resulted in inhibited growth, increases of GOT, GPT, alkaline phosphatase, erythrocyte osmotic resistance and leukocyte alkaline phosphatase, and enlargements of livers, kidneys and adrenal glands. The LD50 values of DMA and MP, administered intraperitoneally to mice, were 2800mg/kg and 2310mg/kg respectively. |
| Descriptors (primary) |
dimethylacetamide; methylpyrrolidinone; enamelling; toxicology |
| Descriptors (secondary) |
leukocytes; glutamic-pyruvic transaminase; glutamic-oxalacetic transaminase; biological effects; exposure evaluation; animal experiments; blood-cell anomalies |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Surface treatment
Heterocyclic compounds
Amides
|
