| Document ID (ISN) | 36185 |
| CIS number |
81-1409 |
| ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Pazderová-Vejlupková J., Němcová M., Pícková J., Jirásek L., Lukáš E. |
| Title |
Development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men. |
| Bibliographic information |
Jan.-Feb. 1981, Vol.36, No.1, p.5-11. Illus. 9 ref. |
| Abstract |
A 10 year follow-up on 55 men exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin in 1968-69 has yielded the following results: The majority of patients developed chloracne and 11 manifested porphyria cutanea tarda; about 50% of the subjects experienced metabolic disturbances such as pathologically elevated lipids with abnormalities in the lipoprotein spectrum; 40% had pathological changes in the glucose tolerance test; one third exhibited biochemical deviations indicative of a mild liver lesion which was histologically revealed to be light steatosis, periportal fibrosis or activation of Kuppfer cells; liver tissues fluoresced in ultraviolet light. 17 persons showed evidence of nervous system focal damage with predominance of peripheral neuron lesion of the lower extremities; most patients suffered from psychological disorders which diminished with time. The first patient to die was the one who had exhibited the most severe signs of intoxication; the cause of death was a rare form of cerebral atherosclerosis. |
| Descriptors (primary) |
neurotoxic effects; hepatic damage; chloracne; hyperlipaemia; tetrachlorodibenzodioxin |
| Descriptors (secondary) |
herbicides; atherosclerosis; biological effects; porphyria cutanea tarda; long-term study; metabolic disturbances |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Heterocyclic compounds
Blood diseases
Skin diseases
Diseases of the nervous system
Liver diseases
|
