Document ID (ISN) | 36185 |
CIS number |
81-1409 |
ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
Year |
1981 |
Convention or series no. |
|
Author(s) |
Pazderová-Vejlupková J., Němcová M., Pícková J., Jirásek L., Lukáš E. |
Title |
Development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men. |
Bibliographic information |
Jan.-Feb. 1981, Vol.36, No.1, p.5-11. Illus. 9 ref. |
Abstract |
A 10 year follow-up on 55 men exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin in 1968-69 has yielded the following results: The majority of patients developed chloracne and 11 manifested porphyria cutanea tarda; about 50% of the subjects experienced metabolic disturbances such as pathologically elevated lipids with abnormalities in the lipoprotein spectrum; 40% had pathological changes in the glucose tolerance test; one third exhibited biochemical deviations indicative of a mild liver lesion which was histologically revealed to be light steatosis, periportal fibrosis or activation of Kuppfer cells; liver tissues fluoresced in ultraviolet light. 17 persons showed evidence of nervous system focal damage with predominance of peripheral neuron lesion of the lower extremities; most patients suffered from psychological disorders which diminished with time. The first patient to die was the one who had exhibited the most severe signs of intoxication; the cause of death was a rare form of cerebral atherosclerosis. |
Descriptors (primary) |
neurotoxic effects; hepatic damage; chloracne; hyperlipaemia; tetrachlorodibenzodioxin |
Descriptors (secondary) |
herbicides; atherosclerosis; biological effects; porphyria cutanea tarda; long-term study; metabolic disturbances |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
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Browse category(ies) |
Heterocyclic compounds Blood diseases Skin diseases Diseases of the nervous system Liver diseases
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