| Document ID (ISN) | 33852 |
| CIS number |
80-1341 |
| ISSN - Serial title |
0020-7136 - International Journal of Cancer |
| Year |
1979 |
| Convention or series no. |
|
| Author(s) |
Taylor G., Kumar S., Brenchley P., Wilson P., Costello B., Shaw G.H. |
| Title |
Immunosurveillance in pre-malignant occupational bladder disease. |
| Bibliographic information |
1979, Vol.23, p.487-493. Illus. 17 ref. |
| Abstract |
The concept of immune surveillance holds that tumour cells are recognised as foreign and many are eliminated before the stage of diagnosable malignancy. Workers exposed to 1-naphthylamine, 2-naphthylanine, and/or benzidine, were studied by comparing their immunoreactivity against bladder cancer cells and a control cancer cell with that found in normal subjects and in patients with bladder cancer. There were equivalent increases in specific reactivity against bladder cancer cells in clinically normal carcinogen-exposed workers and in patients with bladder cancer. Increases in reactivity are related to degree of exposure and to early malignant changes of the urothelium. Immune recognition of tumour antigens occurs before development of overt malignancy. |
| Descriptors (primary) |
carcinogens; naphthylamines; bladder; immunology; early diagnosis |
| Descriptors (secondary) |
lymphocytes; 1-naphthylamine; 2-naphthylamine; comparative study; histopathology; dose-response relationship; bladder tumour |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Aromatic amines
|
