| Document ID (ISN) | 31157 |
| CIS number |
79-674 |
| ISSN - Serial title |
0032-6291 - Pracovní lékařství |
| Year |
1978 |
| Convention or series no. |
|
| Author(s) |
Vlčková A., Ulrich L., Alföldi J., Babinská M. |
| Title |
Protective action of disodium cromoglycate on alveolar macrophage exposed to fibrogenic silica |
| Original title |
Antideštruktivny účinok disodium chromoglykátu sledovaný na alveolárnych makrofágoch, vystavených fibrogennému SiO2 [in Slovak] |
| Bibliographic information |
Aug. 1978, Vol.30, No.7, p.252-255. Illus. 12 ref. |
| Abstract |
The lesions produced by fibrogenic silica, and the protection afforded by disodium cromoglycate (DSG), were studied in vitro. The number of alveolar macrophages that died when cultured with silica increased with the silica concentration. At concentrations of 1,000µg per million alveolar macrophages, all cells were dead. Treatment of the 1,000µg silica dose with 200µg DSG reduced the proportion of dead cells to 25.92%. Spectrographic studies of silica, DSG, and DSG-treated silica excluded the hypothesis of preferential linkage. DSG appears to affect the intensity of the enzyme reaction associated with phagocytosis, as the fall in acid phosphatases confirms. |
| Descriptors (primary) |
disodium cromoglycate; protective pharmacological agents; fibrogenic effects; respirable dust; silica |
| Descriptors (secondary) |
phagocytic activity; macrophages; cell culture; in vitro experiments; enzyme activity |
| Document type |
- |
| Subject(s) |
Dust, aerosols and related diseases
|
| Broad subject area(s) |
|
| Browse category(ies) |
Heterocyclic compounds
|
