| Document ID (ISN) | 24806 |
| CIS number |
76-725 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Clay K.L., Murphy R.C., Watkins W.D. |
| Title |
Experimental methanol toxicity in the primate: Analysis of metabolic acidosis. |
| Bibliographic information |
Oct. 1975, Vol.34, No.1, p.49-61. Illus. 36 ref. |
| Abstract |
Methanol was administered to rats, rhesus monkeys (Macaca mulatta), and pigtail monkeys (Macaca nemestrina). Of these animals, only the pigtail monkey reliably developed a severe metabolic organic acidosis resembling that observed in humans. Blood and urine specimens drawn from methanol-treated pigtail monkeys were analysed for organic acid content by gas chromatography - mass spectroscopy (GC-MS), and specific assays were performed for formate. A preliminary study suggested that, after methanol administation to pigtail monkeys, formate concentrations may be significantly greater in the vitreous humour than in the blood, a finding that may have particular significance in methanol blindness. The anion gap resulting during methanol acidosis was accounted for in full by increased blood concentrations of formate. Systemic formate concentrations remained low in rats and monkeys which failed to become acidotic following methanol administration. Formate appears therefore to play a role comparable to that of formaldehyde in the toxicity of methanol. |
| Descriptors (primary) |
methanol; acid-base balance; metabolic disturbances; toxicology |
| Descriptors (secondary) |
formates; ophthalmotoxic effects; animal experiments; toxicity evaluation |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Endocrine diseases
Blood diseases
|
