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Document ID (ISN)24709
CIS number 76-449
Year 1975
Convention or series no.
Author(s) Lebigot A.
Title Study of renal function and histology in workers chronically exposed to lead in the working environment
Original title Etude de la fonction et de l'histologie rénale chez les sujets soumis à une exposition chronique au plomb en milieu professionnel. [in French]
Bibliographic information Université de Paris VI, Faculté de médecine Pitié - Salpêtrière, Paris, France, 1975. 95p. ILlus. 93 ref.
Abstract M.D. thesis. Detailed description of 12 cases of occupational lead poisoning; 10 of the patients, who worked in a hot environment, had high urinary lead levels, a typical sign of lead-induced kidney damage. In all 12 cases a systematic battery of tests for kidney function was carried out, with a complete clinical examination, biological tests and, most important, histological examination. The results, compared with the patient's medical history and clinical picture, showed the following characteristic features: renal insufficiency was rarely present; there were no signs of tubular insufficiency; hypertension was frequent (but could not be definitely ascribed to lead poisoning); intranuclear inclusions were found in the tubular cells (frequently seen in optic microscopy and twice in electron microscopy, associated with renal insufficiency. Advice on conditions to be observed before workers with diagnosed lead poisoning can be allowed to return to work.
Descriptors (primary) histological effects; hot workplaces; renal damage; lead
Descriptors (secondary) poisoning; case study; France; renal function tests; thesis; histopathology; rehabilitation
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Diseases of the kidney and the urinary system
Lead and compounds
Inorganic substances
Heat and cold