| Document ID (ISN) | 23306 |
| CIS number |
75-1328 |
| ISSN - Serial title |
Trudove na Instituta po higiena, ohrana na truda i profesionalni zaboljavanija |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Velizarov A., Georgiev A., Hadžieva J. |
| Title |
Histopathological liver changes after chronic experimental phenol poisoning |
| Original title |
Histologični promeni v černija drob pri eksperimentalno hronično otravjane s fenol [in Bulgarian] |
| Bibliographic information |
1974, Vol.22, No.1, p.141-146. 4 ref. |
| Abstract |
Results of research in 35 rabbits given 0.18g/kg phenol daily for 7-35 days by the intravenous route. The authors noted severe dystrophic changes (non-fatty parenchymal and vacuolar dystrophy) of the hepatic parenchyma, necrobiotic lesions of the hepatocytes, a considerable decline (to complete disappearance) in glycogen and a very great fall in cytoplasmic ribonucleic acid. In animals in which administration was stopped after 35 days they noted a reversal of the dystrophic processes and the return of glycogen and RNA levels in the liver cells to normal values. |
| Descriptors (primary) |
phenol; hepatotoxic effects; chronic poisoning; toxicology; hepatic damage |
| Descriptors (secondary) |
liver; histopathology; animal experiments; dystrophy |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Liver diseases
Phenols and phenolic compounds
|
