| Document ID (ISN) | 23220 |
| CIS number |
75-1069 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Beatty P.W., Lembach K.J., Holscher M.A., Neal R.A. |
| Title |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mammalian cells in tissue cultures. |
| Bibliographic information |
Feb.1975, Vol.131, No.2, p.309-312. 4 ref. |
| Abstract |
A study was made of this substance, a contaminant of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5 T), to ascertain whether its toxic effect in mammals is due to inhibition of mitosis. In contrast with the results using plant endosperm cells, statistical analysis of growth rates and morphological studies using electron microscopy revealed no significant difference in growth patterns and no ultrastructural changes in the control or TCDD-treated cell lines studied. |
| Descriptors (primary) |
herbicides; cytotoxic effects; toxicology; tetrachlorodibenzodioxin |
| Descriptors (secondary) |
trichlorophenoxyacetic acid; electron microscopy; cell culture; in vitro experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Heterocyclic compounds
Agricultural chemicals
|
