| Document ID (ISN) | 22950 |
| CIS number |
75-767 |
| ISSN - Serial title |
0301-0279 - Revue française des maladies respiratoires |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Roujeau J., Noguès C., Leclerc J.P. |
| Title |
Paraquat poisoning - anatomical, clinical and experimental study |
| Original title |
Intoxication par le paraquat - Etude anatomo-clinique et expérimentale. [in French] |
| Bibliographic information |
1974, Vol.2, No.1, p.65-74. Illus. 13 ref. |
| Abstract |
This article recalls the clinical aspects of paraquat (1,1'-dimethyl-4,4'-bipyridinium) poisoning, referring to 2 observed cases in which the ultrastructure of the lung tissue was studied. The authors describe an experimental study, in which paraquat was administered to rats by intraperitoneal injection, enabling the authors to detect initial lesions which cannot be observed in man: interstitial oedema associated with endothelial and epithelial cell changes in the alveolar lining preceding the sclerogenous development. The authors discuss the mode of action of paraquat, particularly on the pulmonary surfactant, referring to the particular characteristics of the pulmonary ultrastructure observed by them. |
| Descriptors (primary) |
poisoning; paraquat; pulmonary oedema; pneumotoxic effects; toxicology |
| Descriptors (secondary) |
herbicides; case study; autopsy; animal experiments; histopathology; paraquat chloride |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Heterocyclic compounds
|
