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CISDOC database

Document ID (ISN)22206
CIS number 75-127
ISSN - Serial title Works of the United Research Institute of Hygiene and Industrial Safety
Year 1972
Convention or series no.
Author(s) Zlateva M., Hadjieva Y.
Title Histological changes in the internal organs of experimental animals under the effect of phenol.
Bibliographic information 1972, Vol.23, p.109-118. Illus. 13 ref.
Abstract Account of animal experiments carried out to study the histological and histochemical changes induced by a single dose of phenol (1/10 of the lethal dose 50 = 0.18g/kg) in the liver, lungs, myocardium, aorta and small intestine. The authors observed dystrophic, and sometimes even necrotic, liver cell changes which were particularly evident 35 days after the administration of phenol. The changes observed in the tissues of the other organs showed that phenol is not only hepatotoxic, but also affects other parenchymatous organs including the large arteries.
Descriptors (primary) histological effects; cytotoxic effects; toxicology; phenol
Descriptors (secondary) hepatotoxic effects; histopathology; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Phenols and phenolic compounds