| Document ID (ISN) | 21877 |
| CIS number |
74-1934 |
| ISSN - Serial title |
0028-4793 - New England Journal of Medicine |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
McGill D.B., Motto J.D. |
| Title |
An industrial outbreak of toxic hepatitis due to methylenedianiline. |
| Bibliographic information |
8 Aug. 1974, Vol.291, No.6, p.278-282. Illus. 54 ref. |
| Abstract |
Between 1966 and 1972, 12 young male workers exposed to 4,4'-methylenedianiline (4,4'-diaminodiphenylmethane) developed hepatitis manifesting the following clinical features: a short prodromal period, severe right-upper-quadrant pain, high fever and chills, followed by jaundice. All recovered in 7 weeks. When re-examined 9 months to 5 1/2 years later, all were without clinical or biochemical evidence of chronic liver disease. Circumstantial evidence in the 12 cases suggested that the skin was the major portal of entry of the toxic compound. Pending the development of an automated system requiring no worker contact with methylenedianiline, protective suits with attached rubber gloves were introduced and worn by all exposed workers. No further cases of hepatitis occurred. |
| Descriptors (primary) |
methylenedianiline; manufacture of dielectric materials; toxic hepatitis |
| Descriptors (secondary) |
protective gloves; protective clothing; skin absorption; case study; symptoms; hepatotoxic effects |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Manufacturing of electrical appliances and equipment
Liver diseases
Aromatic amines
|
