| Document ID (ISN) | 21858 |
| CIS number |
74-1926 |
| ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Traiger G.J., Plaa G.L. |
| Title |
Chlorinated hydrocarbon toxicity - Potentiation by isopropyl alcohol and acetone. |
| Bibliographic information |
May 1974, Vol.28, No.5, p.276-278. 10 ref. |
| Abstract |
In experiments with mice it was shown that pre-treatment with isopropyl alcohol or acetone augmented the hepatotoxicity of chloroform, 1,1,2-trichloroethane and trichloroethylene. The most marked potentiation was seen with chloroform. There was no augmentation of hepatic dysfunction with 1,1,1-trichloroethane. The study indicates that the ability of isopropyl alcohol or acetone to potentiate the hepatotoxicity of chlorinated hydrocarbons is proportional to the basic hepatotoxicity of the solvent involved. |
| Descriptors (primary) |
acetone; isopropyl alcohol; synergism; chlorinated hydrocarbons; toxicology |
| Descriptors (secondary) |
hepatotoxic effects; chloroform; 1,1,2-trichloroethane; animal experiments; trichloroethylene |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Ketones
Halogenated hydrocarbons
|
