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CISDOC database

Document ID (ISN)21858
CIS number 74-1926
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1974
Convention or series no.
Author(s) Traiger G.J., Plaa G.L.
Title Chlorinated hydrocarbon toxicity - Potentiation by isopropyl alcohol and acetone.
Bibliographic information May 1974, Vol.28, No.5, p.276-278. 10 ref.
Abstract In experiments with mice it was shown that pre-treatment with isopropyl alcohol or acetone augmented the hepatotoxicity of chloroform, 1,1,2-trichloroethane and trichloroethylene. The most marked potentiation was seen with chloroform. There was no augmentation of hepatic dysfunction with 1,1,1-trichloroethane. The study indicates that the ability of isopropyl alcohol or acetone to potentiate the hepatotoxicity of chlorinated hydrocarbons is proportional to the basic hepatotoxicity of the solvent involved.
Descriptors (primary) acetone; isopropyl alcohol; synergism; chlorinated hydrocarbons; toxicology
Descriptors (secondary) hepatotoxic effects; chloroform; 1,1,2-trichloroethane; animal experiments; trichloroethylene
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Alcohols
Ketones
Halogenated hydrocarbons