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Document ID (ISN)21834
CIS number 74-2069
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1974
Convention or series no.
Author(s) Mundy R.L., Hall L.M., Teague R.S.
Title Pyrazole as an antidote for ethylene glycol poisoning.
Bibliographic information May 1974, Vol.28, No.2, p.320-322. 12 ref.
Abstract Pyrazole, a potent alcohol dehydrogenase inhibitor, given intraperitoneally to mice in a single dose of 300mg/kg, increased significantly the LD50 of orally-administered ethylene glycol. It appears to act like ethanol in preventing conversion of glycol to more toxic metabolites. Although pyrazole is a toxic chemical and may cause damage in several organs in experimental animals, the compound has been used in experimental studies in man; its use on a one-time basis in life-threatening poisoning might be an acceptable risk.
Descriptors (primary) ethylene glycol; pyrazole; antidote treatment
Descriptors (secondary) animal experiments; metabolic process
Document type -
Subject(s) Medicine, hygiene and first aid
Broad subject area(s)
Browse category(ies) Alcohols
Heterocyclic compounds