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Document ID (ISN)20833
CIS number 74-673
ISSN - Serial title 0013-9351 - Environmental Research
Year 1973
Convention or series no.
Author(s) Zaidi S.H., Shanker R., Dogra R.K.S.
Title Experimental infective pneumoconiosis: Effect of asbestos dust and Candida albicans infection on the lungs of rhesus monkeys.
Bibliographic information Sep. 1973, Vol.6, No.3, p.274-286. Illus. 24 ref.
Abstract Candida albicans and amosite dust together produced, after intertracheal inoculation, extensive collagenous fibrosis at 330 days in monkeys. The lesions produced by amosite dust alone comprised fine fibrosis around bronchioles and blood vessels and moderate interstitial fibrosis. Candida albicans alone caused acute inflammatory reaction in the early stages while at the termination of the experiment (330 days) scant evidence of candidiasis remained. It may be concluded that the extensive pulmonary fibrosis in the presence of dust is related to the simultaneous presence of organisms like C. albicans, the exact mechanism of its production requiring further investigation.
Descriptors (primary) Candida albicans; asbestos; dust; collagenous pneumoconiosis; infectious diseases
Descriptors (secondary) amosite; animal experiments; connective tissue development; candidiasis
Document type -
Subject(s) Dust, aerosols and related diseases
Broad subject area(s)
Browse category(ies) Asbestos
Mycoses
Bacterial and parasitic diseases
Pneumoconioses