| Document ID (ISN) | 19857 |
| CIS number |
72-2167 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1972 |
| Convention or series no. |
|
| Author(s) |
Šabad L.M., Pylev L.N., Nasyrov R.L. |
| Title |
The effect of various physical characteristics of different types of industrial soot on their release of carcinogenic benzo(a)pyrene |
| Original title |
Rol' nekotoryh fizičeskih svojstv različnyh promyšlennyh vidov saži pri vydelenii iz nih kancerogennogo uglevodoroda benz(a)pirena [in Russian] |
| Bibliographic information |
Jan. 1972, Vol.16, No.1, p.9-12. 22 ref. |
| Abstract |
Chemical analysis of 11 soots showed they all contained benzo(a)pyrene; benzopyrene concentration in very fine particulate soot was much higher than in coarse particulate soot. Mice were given subcutaneous injections of 2 types of soot (29 and 80nm particles) which had previously absorbed 1mg benzopyrene; carcinogenic activity was much less than that of benzopyrene not adsorbed on soot, that had been administered to controls. Intratracheal administration of pure soot and soot mixed with benzopyrene revealed that fine particulate soot led to longer lung retention of benzopyrene than was the case with coarse soot or pure benzopyrene. Tumour frequency and morphology also depended on the composition of the administered mixture. |
| Descriptors (primary) |
carcinogens; soot; benzo(a)pyrene; respirable dust |
| Descriptors (secondary) |
animal experiments; lung deposition |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Aromatic hydrocarbons
|
