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CISDOC database

Document ID (ISN)19853
CIS number 72-2514
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1972
Convention or series no.
Author(s) Bruckner J.V., Guess W.L.
Title Morphological skin reactions to 2-chloroethanol
Bibliographic information May 1972, Vol.22, No.1, p.29-44. Illus. 27 ref.
Abstract 2-Chloroethanol and ethanol are acutely toxic to various animal tissues. This study was undertaken to assess more accurately the nature of the damage to the dermal and epidermal structures of rabbits. A classical inflammatory reaction was noted, accompanied by coagulative necrosis in zones of higher alcoholic concentration. Degenerative subcellular changes were also revealed by electron microscopy. Both ethanol and 2-chloroethanol exerted similar effects, although the latter was always more potent.
Descriptors (primary) 2-chloroethanol; pathomorphology; dermatological effects
Descriptors (secondary) acute toxicity; ethanol; degenerative processes; animal experiments; inflammations; skin; necrosis
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Alcohols
Skin diseases