Document ID (ISN) | 19846 |
CIS number |
72-2516 |
ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
Year |
1972 |
Convention or series no. |
|
Author(s) |
Jacobson K.H. |
Title |
Acute oral toxicity of mono and di-alkyl ring-substituted derivatives of aniline |
Bibliographic information |
May 1972, Vol.22, No.1, p.153-154. 1 ref. |
Abstract |
A short communication on oral toxicity studies of methyl, ethyl and isopropyl ring-substituted aniline derivatives in the rat. Oral LD50 values were determined for: 2-methylaniline; 2,6-dimethylaniline; 2-ethylaniline; 2,6-diethylaniline; 2-isopropylaniline; 2,6-diisopropylaniline; and 2-methyl-6-ethylaniline. LD50 values are about the same in mono-substituted anilines for 1- to 3-carbon substituents, but increase in di-substituted anilines as carbon chain increases from C1 to C3. Di-substituted anilines are less toxic than mono-substituted anilines when C=2 and 3, but not when C=1. |
Descriptors (primary) |
aromatic amines; toxicology; aniline |
Descriptors (secondary) |
ingestion; lethal dose 50; animal experiments; toxicity evaluation |
Document type |
D - Periodical articles |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Aromatic amines
|