ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)19846
CIS number 72-2516
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1972
Convention or series no.
Author(s) Jacobson K.H.
Title Acute oral toxicity of mono and di-alkyl ring-substituted derivatives of aniline
Bibliographic information May 1972, Vol.22, No.1, p.153-154. 1 ref.
Abstract A short communication on oral toxicity studies of methyl, ethyl and isopropyl ring-substituted aniline derivatives in the rat. Oral LD50 values were determined for: 2-methylaniline; 2,6-dimethylaniline; 2-ethylaniline; 2,6-diethylaniline; 2-isopropylaniline; 2,6-diisopropylaniline; and 2-methyl-6-ethylaniline. LD50 values are about the same in mono-substituted anilines for 1- to 3-carbon substituents, but increase in di-substituted anilines as carbon chain increases from C1 to C3. Di-substituted anilines are less toxic than mono-substituted anilines when C=2 and 3, but not when C=1.
Descriptors (primary) aromatic amines; toxicology; aniline
Descriptors (secondary) ingestion; lethal dose 50; animal experiments; toxicity evaluation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Aromatic amines