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Document ID (ISN)18765
CIS number 73-1341
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1972
Convention or series no.
Author(s) Bingham E.
Title Responses of alveolar macrophages - I. Inhalation of lead and nickel
Bibliographic information Dec. 1972, Vol.25, No.6, p.406-414. Illus. 13 ref.
Abstract Rats were subjected for one or several weeks to the inhalation of soluble and insoluble aerosols of lead and nickel (PbCl2, Pb2O3, NiCl2, NiO) at concentrations near or below the occupational TLVs. The number of alveolar macrophages was significantly increased after exposure to NiO, significantly decreased with Pb2O3 and not significantly altered with PbCl2 and NiCl2. The histopathological examination (light microscopy) of the lungs revealed changes after the inhalation of both nickel compounds. The experimental results suggest that the level of the current TLV for nickel (1000µg/m3) should be re-evaluated, as it may be too high.
Descriptors (primary) threshold limit values; nickel and compounds; biological effects; inhalation; lead and compounds
Descriptors (secondary) macrophages; nickel; lead; lung deposition; health hazards; animal experiments; histopathology; light microscopy; inhalation tests; respiratory diseases
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Occupational exposure limits
Nickel and compounds
Lead and compounds
Inorganic substances