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CISDOC database

Document ID (ISN)112530
CIS number 12-0202
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2012
Convention or series no.
Author(s) Betenia N., Costello S., Eisen E.A.
Title Risk of cervical cancer among female autoworkers exposed to metalworking fluids
Bibliographic information Jan. 2012, Vol.38, No.1, p.78-83. 33 ref.
Internet access Risk_of_cervical_cancer_[BUY_THIS_ARTICLE] [in English]
Abstract Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer. This study examined cervical cancer in relation to occupational exposure to metalworking fluids (MWF), which are complex mixtures containing several known carcinogens. A cohort of 4374 female autoworkers was followed from 1985-2004 for cancer diagnosis, with a focus on cervical cancer. Pooled logistic regression was used to model the relationship between exposure to three different types of MWF, selected constituents, and incidence of cervical cancer. Based on 40 cases, SIRs were statistically significantly elevated for both race-specific subgroups: 3.30 and 2.43, respectively for Caucasian and African-American women. The standard mortality ratio (SMR) was also statistically significantly elevated for Caucasian women (3.44) based on seven observed deaths. However there was no association with oil-based straight fluid. Relative risks for soluble and synthetic MWF and nitrosamines were modestly elevated but not statistically significant.
Descriptors (primary) cutting fluids; mortality; uterine cancer; motor vehicle industry; risk factors
Descriptors (secondary) cohort study; statistical evaluation; women; race-linked differences
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Women
Motor vehicle manufacturing industry