|Document ID (ISN)||112530|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Betenia N., Costello S., Eisen E.A.
||Risk of cervical cancer among female autoworkers exposed to metalworking fluids
||Jan. 2012, Vol.38, No.1, p.78-83. 33 ref.
||Risk_of_cervical_cancer_[BUY_THIS_ARTICLE] [in English]
||Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer. This study examined cervical cancer in relation to occupational exposure to metalworking fluids (MWF), which are complex mixtures containing several known carcinogens. A cohort of 4374 female autoworkers was followed from 1985-2004 for cancer diagnosis, with a focus on cervical cancer. Pooled logistic regression was used to model the relationship between exposure to three different types of MWF, selected constituents, and incidence of cervical cancer. Based on 40 cases, SIRs were statistically significantly elevated for both race-specific subgroups: 3.30 and 2.43, respectively for Caucasian and African-American women. The standard mortality ratio (SMR) was also statistically significantly elevated for Caucasian women (3.44) based on seven observed deaths. However there was no association with oil-based straight fluid. Relative risks for soluble and synthetic MWF and nitrosamines were modestly elevated but not statistically significant.
||cutting fluids; mortality; uterine cancer; motor vehicle industry; risk factors
||cohort study; statistical evaluation; women; race-linked differences
||D - Periodical articles
||Metal production and metalworking
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens
Motor vehicle manufacturing industry