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CISDOC database

Document ID (ISN)112528
CIS number 12-0200
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2012
Convention or series no.
Author(s) Nakata A., Takahashi M., Irie M.
Title Association of overtime work with cellular immune markers among healthy daytime white-collar employees
Bibliographic information Jan. 2012, Vol.38, No.1, p.56-64. Illus. 47 ref.
Internet access Association_of_overtime_work_[BUY_THIS_ARTICLE] [in English]
Abstract This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women) provided a blood sample for the measurement of circulating immune (natural killer - NK, B, and T) cells and NK cell cytotoxicity (NKCC) and completed a questionnaire on their hours of overtime work. Data were subjected to stepwise linear regression analyses controlling for confounders. Overtime work was mainly related to short sleep duration, increased weight and reduced job satisfaction; it was more prevalent among men than women and among younger and married employees. The amount of overtime was inversely associated with NK cell counts but was not associated with NKCC, NKCC/NK cell ratio, T or B cells. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense.
Descriptors (primary) hours of work; work time schedules; state of health; immunity; white-collar workers
Descriptors (secondary) Japan; statistical evaluation; sex-linked differences; risk factors
Document type D - Periodical articles
Subject(s) Occupational physiology
Broad subject area(s) Occupational medicine, epidemiology
Physiology, ergonomics
Browse category(ies) Hours of work