|Document ID (ISN)||112528|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Nakata A., Takahashi M., Irie M.
||Association of overtime work with cellular immune markers among healthy daytime white-collar employees
||Jan. 2012, Vol.38, No.1, p.56-64. Illus. 47 ref.
||Association_of_overtime_work_[BUY_THIS_ARTICLE] [in English]
||This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women) provided a blood sample for the measurement of circulating immune (natural killer - NK, B, and T) cells and NK cell cytotoxicity (NKCC) and completed a questionnaire on their hours of overtime work. Data were subjected to stepwise linear regression analyses controlling for confounders. Overtime work was mainly related to short sleep duration, increased weight and reduced job satisfaction; it was more prevalent among men than women and among younger and married employees. The amount of overtime was inversely associated with NK cell counts but was not associated with NKCC, NKCC/NK cell ratio, T or B cells. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense.
||hours of work; work time schedules; state of health; immunity; white-collar workers
||Japan; statistical evaluation; sex-linked differences; risk factors
||D - Periodical articles
|Broad subject area(s)
||Occupational medicine, epidemiology
||Hours of work