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Document ID (ISN)112465
CIS number 12-0189
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Orsi L., Monnereau A., Dananche B., Berthou C., Fenaux P., Marit G., Soubeyran P., Huguet F., Milpied N., Leporrier M., Hemon D., Troussard X., Clavel J.
Title Occupational exposure to organic solvents and lymphoid neoplasms in men: Results of a French case-control study
Bibliographic information Oct. 2010, Vol.67, No.10, p.664-672. 42 ref.
Internet access Occupational_exposure_to_organic_solvents_[BUY_THIS_ARTICLE] [in English]
Abstract The objective of this study was to investigate the role of occupational exposure to solvents in the occurrence of lymphoid neoplasms (LNs) in men. The data were generated by a French hospital-based case-control study, conducted in six centres in 2000-2004. The cases were incident cases aged 18-75 years with a diagnosis of LN. During the same period, controls of the same age and gender as the cases were recruited in the same hospitals, mainly in the orthopaedic and rheumatological departments. Exposure to solvents was assessed using standardized occupational questionnaires and case-by-case expert assessment. Specific quantification of benzene exposure was attempted. The analyses included 491 male patients (244 cases of non-Hodgkin's lymphoma (NHL), 87 of Hodgkin's lymphoma, 104 of lymphoproliferative syndrome and 56 of multiple myeloma) and 456 male controls. Data were analyzed using unconditional logistic regression. Solvent exposure, all solvents considered together, was marginally associated with NHL (odds ratio OR 1.4), but not with other LNs. No association with the main chemical series of solvents was observed. There was no trend with the average intensity or frequency of exposure. Exposure to pure benzene was not significantly related to NHL (OR 3). The highest maximum intensities of benzene exposure were associated with diffuse large cell lymphoma (OR 2). Findings provide estimates compatible with the hypothesis that exposures to pure benzene and high benzene intensities may play a role in some NHL. There was no evidence for a role of other organic solvents in the occurrence of LN.
Descriptors (primary) France; organic solvents; neoplasms; male workers; risk factors
Descriptors (secondary) benzene; lymphoma; case-control study; statistical evaluation; job-exposure relation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens