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CISDOC database

Document ID (ISN)112435
CIS number 12-0181
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Cave M., Falkner K.C., Henry L., Costello B., Gregory B., McClain C.J
Title Serum cytokeratin 18 and cytokine elevations suggest a high prevalence of occupational liver disease in highly exposed elastomer/polymer workers
Bibliographic information Oct. 2011, Vol.53, No.10, p.1128-1133. 42 ref.
Internet access Serum_cytokeratin_18_[BUY_THIS_ARTICLE] [in English]
ILO_LABORDOC_[INTRANET_ACCESS] [in English]
Abstract Cytokeratin 18 (CK18) is a novel serologic biomarker for occupational liver disease. The purpose of this study was to determine the prevalence of CK18 elevation in elastomer/polymer workers exposed to acrylonitrile, 1,3-butadiene, and styrene. A total of 82 chemical workers were evaluated. Cytokeratin 18 was determined by enzyme-linked immunosorbent assay and proinflammatory cytokines were measured by multi-analyte chemiluminescent detection. Thirty-nine percent (32 of 82) had elevated CK18 levels. The pattern of CK18 elevation was consistent with toxicant-associated steatohepatitis (TASH) in the majority of cases (78%). Tumor necrosis factor α, interleukin-6, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-1 were increased in these workers compared with those with normal CK18 levels. These results suggest a high prevalence of occupational liver disease and TASH in elastomer/polymer workers with elevated proinflammatory cytokines.
Descriptors (primary) ABS; toxic substances; hepatic diseases; exposure tests; chemical industry; risk factors
Descriptors (secondary) butadiene; styrene; acrylonitrile; interleukins; determination in blood; immunology
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Liver diseases
Butadiene
Aromatic hydrocarbons
Chemical industry