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Document ID (ISN)112434
CIS number 12-0180
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Bernstein J.A., Ghosh D., Sublett W.J., Wells H., Levin L.
Title Is trimellitic anhydride skin testing a sufficient screening tool for selectively identifying TMA-exposed workers with TMA-specific serum IgE antibodies?
Bibliographic information Oct. 2011, Vol.53, No.10, p.1122-1127. Illus. 20 ref.
Internet access Is_trimellitic_anhydride_skin_testing_[BUY_THIS_ARTICLE] [in English]
Abstract Trimellitic anhydride (TMA) can elicit specific IgE-mediated immune responses leading to asthma. This single-blinded study investigated the ability of TMA skin testing to identify workers with TMA-serum specific IgE antibodies. Forty TMA-exposed workers who were previously screened for the presence of TMA-IgG and/or IgE serum specific antibodies were skin tested to a TMA-human serum albumin reagent by nurses blinded to their antibody responses. Findings from skin-prick tests were positive in 8 of 11 workers with TMA-serum specific IgE antibodies. Intracutaneous testing, performed only on skin prick testing-negative workers, was positive in two additional workers with TMA-serum specific IgE antibodies. A significant correlation was found between serum and skin test dilutions eliciting positive responses. It is concluded that TMA skin testing provides an alternative and potentially more practical method for monitoring TMA-exposed workers at risk of developing IgE sensitization.
Descriptors (primary) trimellitic anhydride; allergens; immunoglobulins; skin tests; chemical industry
Descriptors (secondary) determination in blood; exposure tests; reliability; description of technique
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Allergies
Chemical industry
Exposure evaluation