|Document ID (ISN)||112434|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Bernstein J.A., Ghosh D., Sublett W.J., Wells H., Levin L.
||Is trimellitic anhydride skin testing a sufficient screening tool for selectively identifying TMA-exposed workers with TMA-specific serum IgE antibodies?
||Oct. 2011, Vol.53, No.10, p.1122-1127. Illus. 20 ref.
||Is_trimellitic_anhydride_skin_testing_[BUY_THIS_ARTICLE] [in English]
ILO_LABORDOC_[INTRANET_ACCESS] [in English]
||Trimellitic anhydride (TMA) can elicit specific IgE-mediated immune responses leading to asthma. This single-blinded study investigated the ability of TMA skin testing to identify workers with TMA-serum specific IgE antibodies. Forty TMA-exposed workers who were previously screened for the presence of TMA-IgG and/or IgE serum specific antibodies were skin tested to a TMA-human serum albumin reagent by nurses blinded to their antibody responses. Findings from skin-prick tests were positive in 8 of 11 workers with TMA-serum specific IgE antibodies. Intracutaneous testing, performed only on skin prick testing-negative workers, was positive in two additional workers with TMA-serum specific IgE antibodies. A significant correlation was found between serum and skin test dilutions eliciting positive responses. It is concluded that TMA skin testing provides an alternative and potentially more practical method for monitoring TMA-exposed workers at risk of developing IgE sensitization.
||trimellitic anhydride; allergens; immunoglobulins; skin tests; chemical industry
||determination in blood; exposure tests; reliability; description of technique
||D - Periodical articles
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology