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CISDOC database

Document ID (ISN)112415
CIS number 12-0236
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Chen M., Ho C.W., Huang Y.C., Wu K.Y., Wu M.T., Jeng H.A., Chen C.J., Shih T.S., Lai C.H., Pan C.H., Chen Y.M.
Title Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels after PAH exposure
Bibliographic information July 2011, Vol.53, No.7, p.812-819. 39 ref.
Internet access Glycine_N-methyltransferase_[BUY_THIS_ARTICLE] [in English]
Abstract The objective of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). The study participants included 289 coke-oven workers from a steel company in Taiwan. Personal air samples, spot urine samples, peripheral blood samples, and questionnaires were used to quantify PAH exposure, oxidative DNA damage, GNMT gene polymorphisms, demographic data, and environmental pollutants. Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates. This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.
Descriptors (primary) Taiwan (China); aromatic hydrocarbons; transferases; coke ovens; metabolic studies; coking plants; steelworks; genetic effects
Descriptors (secondary) breathing atmosphere; 1-hydroxypyrene; DNA; determination in blood; determination in urine; exposure evaluation; questionnaire survey
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Aromatic hydrocarbons
Iron and steel industry