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Document ID (ISN)112395
CIS number 12-0156
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Lipworth L., Sonderman J.S., Mumma M.T., Tarone R.E., Marano D.E., Boice J.D, McLaughlin J.K.
Title Cancer mortality among aircraft manufacturing workers - An extended follow-up
Bibliographic information Sep. 2011, Vol.53, No.9, p.992-1007. 33 ref.
Internet access Cancer_mortality_[BUY_THIS_ARTICLE] [in English]
Abstract In this extended cancer follow-up among 77,943 aircraft workers, comprehensive exposure information enabled detailed classification of trichloroethylene (TCE), perchloroethylene (PCE), mixed solvents and chromate exposures. Exposure to TCE, PCE, mixed solvents or chromates was not associated with increased cancer risk overall or for most cancer sites. Elevated rates compared with the general population were seen for non-Hodgkin lymphoma for PCE exposure, and colon and testicular cancers and multiple myeloma for mixed solvents exposure. Internal cohort analyses, however, showed no significant trends of increasing risk for these cancers with increasing years of exposure to TCE, PCE or mixed solvents. This large, long-term cohort study with comprehensive exposure assessment found no consistent evidence of increased cancer risk overall or by site among aircraft workers, including those with long-term exposure to TCE, PCE, and mixed solvents.
Descriptors (primary) mortality; cancer; aircraft industry; length of exposure; risk factors
Descriptors (secondary) chromates; trichloroethylene; tetrachloroethylene; solvents; long-term study; cohort study
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Aerospace manufacturing and maintenance industry
Halogenated hydrocarbons
Cancer and carcinogens