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Document ID (ISN)112314
CIS number 12-0132
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Clin B., Morlais F., Launoy G., Guizard A.V., Dubois B., Bouvier V., Desoubeaux N., Marquignon M.F., Raffaelli C., Paris C., Galateau-Salle F., Guittet L., Letourneux M.
Title Cancer incidence within a cohort occupationally exposed to asbestos: A study of dose-response relationships
Bibliographic information Nov. 2011, Vol.68, No.11, p.832-836. 29 ref.
Internet access Cancer_incidence_within_a_cohort_[BUY_THIS_ARTICLE] [in English]
Abstract The aim of this study was to analyze the dose-response relationship between occupational asbestos exposure and risk of cancer. It was carried out in the form of a retrospective morbidity study based on 2024 subjects occupationally exposed to asbestos, conducted from 1978 to 2004. Analysis of the dose-response relationship between occupational asbestos exposure, as a time-dependant variable, and risk of cancer was performed using a Cox model. In order to account for the effect of latency, the analysis was conducted with a lag of 10 years. 285 cases of cancers were observed in the cohort. The relative risk of pleuro-peritoneal mesothelioma, lung cancer and colorectal cancer associated with asbestos exposure, adjusted for age as a time-dependant variable and for sex, was correlated with exposure intensity (or average exposure level, AEL). The risk of cancer, whatever the anatomical site, did not increase with the duration of exposure to asbestos. While confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers, this study also suggests a causal relationship between asbestos exposure and colorectal cancer.
Descriptors (primary) asbestos; cancer; dose-response relationship; risk factors
Descriptors (secondary) France; location of injury; long-term study; cohort study; statistical evaluation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens