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Document ID (ISN)112313
CIS number 12-0318
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Smit L.A., Heederik D., Doekes G., Koppelman G.H., Bottema R.W., Postma D.S., Wouters I.M.
Title Endotoxin exposure, CD14 and wheeze among farmers: A gene-environment interaction
Bibliographic information Nov. 2011, Vol.68, No.11, p.826-831. Illus. 33 ref.
Internet access Endotoxin_exposure_[BUY_THIS_ARTICLE] [in English]
Abstract The objective of this study was to assess whether the association between occupational endotoxin exposure and wheeze is modified by innate immunity gene variants. Twenty-four single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 4 (TLR4), TLR2, MD2 and MyD88 were genotyped in 408 agricultural workers with spirometry and questionnaire data on asthma symptoms available. Personal airborne endotoxin exposure levels were estimated in 249 exposure measurements. The association between occupational endotoxin exposure and wheeze in agricultural workers was significantly modified by genetic variants in CD14 and MD2. Findings suggest that carriers of the functional CD14/-260 C allele are more responsive to endotoxin exposure than T allele homozygotes. Implications of these findings are discussed.
Descriptors (primary) bacterial toxins; restrictive ventilatory impairment; immunology; individual susceptibility; agriculture; risk factors
Descriptors (secondary) Netherlands; determination in blood; spirometry; exposure evaluation; questionnaire survey; genetic effects
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Occupational pathology
Broad subject area(s) Biological hazards
Occupational medicine, epidemiology
Browse category(ies) Agriculture
Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards