|Document ID (ISN)||112307|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Lee M.S., Magari S., Christiani D.C.
||Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons
||July 2011, Vol.68, No.7, p.474-478. Illus. 40 ref.
||Cardiac_autonomic_dysfunction_[BUY_THIS_ARTICLE] [in English]
||Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiopulmonary mortality and cardiovascular events. This study investigated the association between a biological marker of PAH exposure, assessed by urinary 1-hydroxypyrene (1-OHP), and heart-rate variability in an occupational cohort of boilermakers. Continuous 24 h monitoring of the ambulatory electrocardiogram (ECG) and pre- and postshift urinary 1-OHP were repeated over extended periods of the work week. Data were subjected to statistical analyses. Findings provide evidence that occupational exposure to PAHs is associated with altered cardiac autonomic function. Acute exposure to PAHs may be an important predictor of cardiovascular disease risk in the work environment.
||aromatic hydrocarbons; polycyclic hydrocarbons; cardiovascular diseases; exposure evaluation; boilermaking; risk factors
||1-hydroxypyrene; determination in urine; electrocardiography; heart rate monitoring; cohort study; statistical evaluation
||D - Periodical articles
||Toxic and dangerous substances
Metal production and metalworking
|Broad subject area(s)
||Occupational medicine, epidemiology