|Document ID (ISN)||112303|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Gaudin R., Marsan P., Ndaw S., Robert A., Ducos P.
||Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: A field study
||June 2011, Vol.84, No.5, p.523-531. Illus. 54 ref.
||Biological_monitoring_of_exposure_[INTERNET_FREE_ACCESS] [in English]
||The aim of this study was to assess workers' exposure to di(2-ethylhexyl) phthalate (DEHP) in the flexible-PVC industry in France by means of biological monitoring. Over five days of pre-and post-shift sampling, three urinary metabolites of DEHP, mono (2-ethylhexyl) phthalate (MEHP), mono (5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP) and 2-ethylhexanoic acid (2-EHA) were quantified in 62 workers and 29 controls from six factories. Analyses were performed by high-performance liquid chromatography with tandem mass spectrometry after on-line extraction. There is clear evidence of occupational exposure of workers in these factories. Values of 250 and 500 ┐g/l (100 and 280 ┐/g creatinine) for MEHP and 5cx-MEPP, respectively, are proposed as guidance values which should prevent high exposures in the flexible-PVC industry, particularly in factories where DEHP compounds or plastisols are employed.
||bis(ethylhexyl) phthalate; polyvinyl chloride; plasticizers; exposure tests; plastics converting industry
||France; urinary metabolites; determination in urine; exposure evaluation; threshold limit values
||D - Periodical articles
||Chemicals, plastics and rubber
Toxic and dangerous substances
|Broad subject area(s)