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Document ID (ISN)112303
CIS number 12-0225
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2011
Convention or series no.
Author(s) Gaudin R., Marsan P., Ndaw S., Robert A., Ducos P.
Title Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: A field study
Bibliographic information June 2011, Vol.84, No.5, p.523-531. Illus. 54 ref.
Internet access Biological_monitoring_of_exposure_[INTERNET_FREE_ACCESS] [in English]
Abstract The aim of this study was to assess workers' exposure to di(2-ethylhexyl) phthalate (DEHP) in the flexible-PVC industry in France by means of biological monitoring. Over five days of pre-and post-shift sampling, three urinary metabolites of DEHP, mono (2-ethylhexyl) phthalate (MEHP), mono (5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP) and 2-ethylhexanoic acid (2-EHA) were quantified in 62 workers and 29 controls from six factories. Analyses were performed by high-performance liquid chromatography with tandem mass spectrometry after on-line extraction. There is clear evidence of occupational exposure of workers in these factories. Values of 250 and 500 ┐g/l (100 and 280 ┐/g creatinine) for MEHP and 5cx-MEPP, respectively, are proposed as guidance values which should prevent high exposures in the flexible-PVC industry, particularly in factories where DEHP compounds or plastisols are employed.
Descriptors (primary) bis(ethylhexyl) phthalate; polyvinyl chloride; plasticizers; exposure tests; plastics converting industry
Descriptors (secondary) France; urinary metabolites; determination in urine; exposure evaluation; threshold limit values
Document type D - Periodical articles
Subject(s) Chemicals, plastics and rubber
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Phthalates
Chemical industry