|Document ID (ISN)||112292|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Jeng H.A., Pan C.H., Diawara N., Chang-Chien G.P., Lin W.Y., Huang C.T., Ho C.K., Wu M.T.
||Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration
||Sep. 2011, Vol.68, No.9, p.653-658. 31 ref.
||Polycyclic_aromatic_hydrocarbon-induced_[BUY_THIS_ARTICLE] [in English]
||This population-based cross-sectional study evaluated the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and immunological measurements using blood samples from coke oven workers exposed to high and low PAH levels. It was conducted from 2008-2009 with coke oven workers and steel-rolling workers as the exposed and control groups, respectively. Questionnaires on basic demographic information were administered. Personal breathing zone and urine samples were collected to quantify personal PAH intake and biological response doses. Immunological and cytokine parameters in serum were analysed. Urinary malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were analysed to determine oxidative stress induced by PAHs in relation to altered humoural immunological status. Results were subjected to statistical evaluation. It was found that coke oven workers with chronic exposure to PAHs may develop immunological alteration. Oxidative stress and lipid peroxidation induced by PAHs may partly explain the alteration in immunological parameters.
||Taiwan (China); aromatic hydrocarbons; polycyclic hydrocarbons; coke ovens; coking plants; immunotoxic effects; risk factors
||breathing atmosphere; lipid peroxides; oxidation; immunoglobulins; urinary metabolites; determination in blood; determination in urine; cross-sectional study; statistical evaluation
||D - Periodical articles
||Metal production and metalworking
|Broad subject area(s)
Occupational medicine, epidemiology
Iron and steel industry