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CISDOC database

Document ID (ISN)112292
CIS number 12-0223
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Jeng H.A., Pan C.H., Diawara N., Chang-Chien G.P., Lin W.Y., Huang C.T., Ho C.K., Wu M.T.
Title Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration
Bibliographic information Sep. 2011, Vol.68, No.9, p.653-658. 31 ref.
Internet access Polycyclic_aromatic_hydrocarbon-induced_[BUY_THIS_ARTICLE] [in English]
Abstract This population-based cross-sectional study evaluated the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and immunological measurements using blood samples from coke oven workers exposed to high and low PAH levels. It was conducted from 2008-2009 with coke oven workers and steel-rolling workers as the exposed and control groups, respectively. Questionnaires on basic demographic information were administered. Personal breathing zone and urine samples were collected to quantify personal PAH intake and biological response doses. Immunological and cytokine parameters in serum were analysed. Urinary malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were analysed to determine oxidative stress induced by PAHs in relation to altered humoural immunological status. Results were subjected to statistical evaluation. It was found that coke oven workers with chronic exposure to PAHs may develop immunological alteration. Oxidative stress and lipid peroxidation induced by PAHs may partly explain the alteration in immunological parameters.
Descriptors (primary) Taiwan (China); aromatic hydrocarbons; polycyclic hydrocarbons; coke ovens; coking plants; immunotoxic effects; risk factors
Descriptors (secondary) breathing atmosphere; lipid peroxides; oxidation; immunoglobulins; urinary metabolites; determination in blood; determination in urine; cross-sectional study; statistical evaluation
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Polycyclic hydrocarbons
Aromatic hydrocarbons
Iron and steel industry